A living list
Spatial transcriptomics (e.g., 10x Xenium or Visium) have the potential to add significant biological depth to clinical pathology. The clearest application is cancer diagnostics, but we're also interested in other applications: transplant, cardiovascular, neuroscience, etc.
Mood is critical to everything, and often very difficult to change. We'd love to be able to modulate it: add a bit of happiness, add a bit of focus, tone down the defensiveness. While the extreme version of this is Brave New World, we think there's a ton of value to be had far before that.
We find it crazy that in 2025, it's still effectively impossible to know what you ate over the course of a day with numerical precision. Existing solutions (taking pictures of food, journaling) are way too difficult. We'd like to see something like an intestinal sensor (perhaps digestible, taken in a pill) that can detect caloric intake and macronutrient composition of said calories (fat, protein, carbs), and send that information to your phone.
If you're building or thinking of building in any of these spaces, or have strong opinions on them, drop us a line: edward@perpetualpolymerase.com
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